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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: Mar 9, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
09:07

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Published on: June 24, 2025

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Topical ivermectin improves allergic skin inflammation.

E Ventre1, A Rozières1, V Lenief1

  • 1CIRI, International Center for Infectiology Research, Université de Lyon, INSERM, U1111, Ecole Normale Supérieure de Lyon, Centre International de Recherche en Infectiologie, Université Lyon 1, CNRS, UMR 5308, Lyon, France.

Allergy
|January 5, 2017
PubMed
Summary
This summary is machine-generated.

Ivermectin (IVM) demonstrates topical anti-inflammatory effects by inhibiting T-cell activation and cytokine production. This finding suggests IVM

Keywords:
T-cell immunityatopic dermatitisivermectinskin inflammatory diseasestopical treatment

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Area of Science:

  • Immunology
  • Dermatology
  • Pharmacology

Background:

  • Ivermectin (IVM) is a common antiparasitic drug.
  • Emerging evidence suggests IVM possesses anti-inflammatory properties.

Purpose of the Study:

  • To investigate the anti-inflammatory activity of Ivermectin.
  • To evaluate IVM's efficacy in a murine model of atopic dermatitis (AD).

Main Methods:

  • Murine model of atopic dermatitis induced by Dermatophagoides farinae.
  • In vitro and in vivo immunological assays.
  • Assessment of T-cell activation, proliferation, and cytokine production.

Main Results:

  • Topical Ivermectin ameliorated allergic skin inflammation.
  • IVM reduced allergen-specific T-cell priming and activation.
  • IVM impaired T-cell proliferation and inflammatory cytokine production.

Conclusions:

  • Ivermectin exhibits topical anti-inflammatory properties.
  • IVM may be a potential therapeutic agent for T-cell-mediated skin diseases.