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POSTAR: a platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
Boqin Hu1, Yu-Cheng T Yang1,2, Yiming Huang1
1MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Center for Plant Biology and Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Nucleic Acids Research
|January 6, 2017
Summary
POSTAR is a new resource detailing RNA-binding protein (RBP) interactions in humans and mice. It maps RBP binding sites to understand post-transcriptional regulation and its links to diseases.
Area of Science:
- Molecular Biology
- Genomics
- Bioinformatics
Background:
- Post-transcriptional regulation by RNA-binding proteins (RBPs) is crucial for gene expression control.
- Characterizing these regulatory networks is essential for understanding cellular function and disease.
Purpose of the Study:
- To introduce POSTAR, a comprehensive resource for post-transcriptional regulatory maps.
- To provide a platform for exploring RBP binding sites and their functional implications.
Main Methods:
- Aggregated and curated experimentally validated and computationally predicted RBP binding sites.
- Integrated diverse data including molecular events, RNA structures, variants, and gene expression.
- Developed a user-friendly search interface for multi-modal data exploration.
Main Results:
- POSTAR houses the largest collection of RBP binding sites (23M experimental, 117M predicted) for human and mouse transcriptomes.
- Annotated transcripts with detailed regulatory information, disease associations, and structural data.
- Identified potential links between RBP binding, RNA structures, and diseases like Li-Fraumeni syndrome.
Conclusions:
- POSTAR systematically annotates post-transcriptional regulatory maps.
- The resource facilitates novel insights into RBP roles in human diseases.