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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Related Experiment Video

Updated: Mar 9, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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Targeting Lipid Metabolic Reprogramming as Anticancer Therapeutics.

Ji-Young Cha1, Ho-Jae Lee1

  • 1Department of Biochemistry, Gachon University College of Medicine, Incheon, Korea.

Journal of Cancer Prevention
|January 6, 2017
PubMed
Summary

Cancer cells alter lipid metabolism for growth. Targeting these metabolic changes offers promising new strategies for cancer therapy.

Area of Science:

  • Oncology and Molecular Biology
  • Cancer Metabolism Research

Background:

  • Cancer cells exhibit metabolic reprogramming, a hallmark of cancer, to support rapid growth and survival.
  • Lipid metabolism is crucial for cancer cells, providing energy, building blocks for membranes, and signaling molecules.

Approach:

  • This review examines the specific alterations in lipid metabolic pathways observed in cancer cells.
  • It highlights recent therapeutic targets, including enzymes and regulatory factors within lipid metabolism.
  • The review also discusses small molecules designed to target these pathways for potential anticancer drug development.

Key Points:

  • Cancer cells significantly alter lipid metabolism to fuel their growth and survival.
  • Dysregulated lipid metabolism presents vulnerabilities that can be exploited for therapeutic intervention.
Keywords:
CancerLipid metabolismLipogenesisTherapeutics

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  • Targeting key enzymes and regulatory factors in cancer lipid metabolism is a promising area for novel anticancer drug discovery.

    • Conclusions:

    • Understanding cancer cell lipid metabolism is critical for developing effective cancer treatments.
    • Targeting lipid metabolic pathways offers a viable strategy for novel anticancer drug development.
    • Further research into lipid metabolic enzymes and regulatory factors will advance cancer therapy.