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Health effects of laser printer emissions: a controlled exposure study.

S Karrasch^1,2, M Simon¹, B Herbig¹

¹Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich, Ludwig-Maximilians-Universität, Munich, Germany.

|January 6, 2017

Summary

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Exposure to laser printing device (LPD) emissions did not cause significant health effects in healthy individuals or asthmatics. Acute responses to high-level LPD particle exposure were minimal, suggesting no clinically relevant impact.

Area of Science:

Environmental Health
Occupational Health
Toxicology

Background:

Ultrafine particles from laser printing devices (LPDs) raise health concerns.
Previous studies suggest potential adverse effects, necessitating controlled exposure research.

Purpose of the Study:

To investigate the acute health effects of exposure to laser printing device emissions.
To assess lung function, inflammatory markers, and immunological responses in humans following controlled LPD exposure.

Main Methods:

Standardized, randomized, cross-over exposure of 23 healthy subjects, 14 mild asthmatics, and 15 symptomatic individuals to low-level (LLE) and high-level (HLE) LPD emissions.
Evaluated lung mechanics (spirometry, plethysmography), gas transfer (TLCO, TLNO), nitric oxide levels, and biomarkers (cytokines, ECP, IgE) before and after 75-minute exposures.

Keywords:

emission exposure laser printer lung function respiratory health ultrafine particles

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Main Results:

No statistically significant changes in lung mechanics or nitric oxide levels were observed across all participants.
A non-significant decrease in volume-related transfer factor for nitric oxide (TLNO) was noted at high-level exposures.
Serum eosinophil cationic protein (ECP) and immunoglobulin E (IgE) increased similarly post-exposure; nasal IL-6 showed a greater increase after low-level exposure.

Conclusions:

Acute, short-term exposure to high levels of laser printing device emissions did not induce clinically significant adverse health effects.
Observed biological responses were small and inconsistent across participant subgroups and measured variables.