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Basic or extended urine sampling to analyse urine production?

Marie-Astrid Denys1, Vansh Kapila2, Jeffrey Weiss3

  • 1Department of Urology, Ghent University Hospital, Ghent, Belgium.

Neurourology and Urodynamics
|January 6, 2017
PubMed
Summary
This summary is machine-generated.

Basic and extended urine collections show good correlation for evaluating urine production. A single nighttime urine sample (3-5 AM) may be the most practical method for assessing renal function profiles.

Keywords:
diagnosisdiuresisnocturianocturnal polyuriaphysiopathology

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Area of Science:

  • Nephrology
  • Urology
  • Clinical Chemistry

Background:

  • Frequency-volume charts objectively assess urine production in patients with nocturia, enuresis, or nocturnal incontinence.
  • Basic (day/night) and extended (3-hourly) urine collections provide insights into circadian patterns of water and solute diuresis, termed renal function profiles.

Purpose of the Study:

  • To evaluate the intra-individual correlation and agreement between renal function profiles derived from basic and extended urine collections.
  • To compare two different extended urine collection methods.
  • To develop a simplified, short-form extended collection method.

Main Methods:

  • Prospective observational study conducted at Ghent University Hospital.
  • Participants provided one basic and two extended 24-hour urine collections.
  • Analysis of urinary osmolality, sodium, and creatinine levels.

Main Results:

  • Moderate to strong correlation observed between basic and extended urinalysis results.
  • Moderate correlation between individual samples in extended collections; weak to strong correlation for mean daytime/nighttime values.
  • Samples collected between 3-5 AM showed highest agreement with mean nighttime renal function values.

Conclusions:

  • Good correlation and agreement exist between basic and extended urine collections for studying urine production mechanisms.
  • The choice of urine sampling method should align with the specific clinical objective.
  • A single nighttime urine sample collected between 3-5 AM offers a practical approach for evaluating renal function.