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Related Experiment Video

Updated: Mar 9, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Salecan-Based pH-Sensitive Hydrogels for Insulin Delivery.

Xiaoliang Qi1, Wei Wei1, Junjian Li1

  • 1Center for Molecular Metabolism, Nanjing University of Science & Technology , Nanjing 210094, China.

Molecular Pharmaceutics
|January 6, 2017
PubMed
Summary
This summary is machine-generated.

New Salecan-based pH-sensitive hydrogels offer controlled insulin delivery. These biocompatible hydrogels release insulin effectively in response to environmental pH changes, showing promise for drug delivery.

Keywords:
2-acrylamido-2-methyl-1-propanesulfonic aciddrug deliveryinsulinpH-sensitive hydrogelssalecan

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Stimuli-responsive polymeric hydrogels are advanced delivery systems for protein/peptide drugs.
  • Controlled dosage and spatiotemporal delivery are key challenges in protein/peptide therapeutics.

Purpose of the Study:

  • To fabricate novel Salecan-based pH-sensitive hydrogels for controlled insulin delivery.
  • To investigate the influence of Salecan on hydrogel properties and insulin release kinetics.

Main Methods:

  • Graft copolymerization of Salecan with 2-acrylamido-2-methyl-1-propanesulfonic acid.
  • Characterization of hydrogel structure, pore size, water content, and water release rate.
  • In vitro insulin release studies at different pH conditions (pH 1.2 and pH 7.4).
  • Biocompatibility assessment through toxicity assays.

Main Results:

  • Salecan effectively modified hydrogel structure, pore size, and water content, enabling tunable insulin release.
  • pH-dependent insulin release was observed: low release at pH 1.2 (gastric) and significantly higher release at pH 7.4 (intestinal).
  • The SGA2 hydrogel formulation showed controlled release profiles, with approximately 26.1 wt% insulin released in 24 h at pH 1.2 and over 50 wt% in 6 h at pH 7.4.
  • Toxicity assays confirmed the biocompatibility of the developed hydrogel carriers.

Conclusions:

  • Salecan-based pH-sensitive hydrogels are effective for controlled insulin delivery.
  • The hydrogels demonstrate tunable drug release based on environmental pH, mimicking physiological conditions.
  • These biocompatible hydrogels represent a promising platform for protein/peptide drug delivery devices.