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Published on: June 21, 2018
Effect of Interleukin-27 Genetic Variants on Atrial Fibrillation Susceptibility
Yu Chen1, Jianhui Zeng2, Rui Zhang3,4
11 Department of Cardiology, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital , Chengdu, China .
Aim:
Atrial fibrillation (AF) is the most common cardiac arrhythmia. No data are available on the association between the polymorphisms of interleukin-27 (IL-27) and AF in the Chinese Han population. This study was performed to determine if polymorphisms within the IL-27 gene are involved in the AF susceptibility.
Methods:
Two hundred seventy AF patients and 303 healthy individuals were examined for two IL-27 gene polymorphisms (rs153109 and rs17855750) by polymerase chain reaction-restriction fragment length polymorphism methodology.
Results:
An association between the IL-27 single nucleotide polymorphism (SNP) rs153109 and AF was found in Chinese Han population. The G allele and GG genotype of rs153109 were associated with increased AF risk (odds ratio [OR]: 1.35, 95% confidence intervals [CI] = 1.06-1.71, p = 0.02 and OR: 1.66, 95% CI = 1.03-2.65, p = 0.03 in the recessive genetic model, respectively). The significance of the association between the GG genotype and AF risk did not survive a Bonferroni's correction. Similarly, no significant differences in the allele and genotype frequencies of the rs17855750 SNP was observed between the AF patients and controls.
Conclusions:
Our findings indicated that the IL-27 genetic polymorphisms may be associated with susceptibility of AF in Chinese Han population.
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