Related Experiment Video
Updated: Mar 9, 2026
04:34
Surgical Treatment of an Endolymphatic Sac Tumor
Published on: May 26, 2023
1.7K
Ewing Sarcoma of the Head and Neck.
Mark A Ellis1, Daniel R Gerry2, David M Neskey1
11 Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
The Annals of Otology, Rhinology, and Laryngology
|January 7, 2017
Summary
Ewing sarcoma of the head and neck (ES-HN) shows improved survival due to smaller tumor size and lower metastatic rates, not distinct clinical behavior. This analysis compared ES-HN to other locations using SEER data.
Area of Science:
- Oncology
- Surgical Oncology
- Epidemiology
Background:
- Ewing sarcoma is a rare bone and soft tissue cancer.
- Ewing sarcoma of the head and neck (ES-HN) is particularly uncommon, with limited prior characterization.
- Previous studies on ES-HN were small retrospective series.
Purpose of the Study:
- To analyze demographic, clinicopathologic, treatment, and survival characteristics of ES-HN.
- To compare ES-HN with Ewing sarcoma at other anatomical locations (ES-other).
- To determine if head and neck location is an independent prognostic factor.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database.
- Compared 183 patients with ES-HN to 3177 patients with ES-other.
- Analyzed survival using Kaplan-Meier and Cox regression models.
Main Results:
- ES-HN tumors were smaller and had lower metastatic rates than ES-other (P < .001).
- ES-HN demonstrated significantly better 10-year disease-specific survival (DSS) and overall survival (OS) (P = .001, P = .015).
- Head and neck location was not an independent prognosticator in multivariate analysis (P = .88).
Conclusions:
- ES-HN does not appear to be a distinct clinical entity from ES-other.
- Improved prognosis in ES-HN is likely attributed to favorable tumor characteristics (size, metastasis).
- Further research may elucidate specific management strategies for ES-HN.
Related Concept Videos
01:26Arteries of the Head and Neck
3.9K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
3.9K
01:03Rous Sarcoma Virus (RSV) and Cancer
6.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.5K
01:19Veins of Head and Neck
6.5K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
6.5K
01:22Sutures of the Skull
13.8K
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
13.8K