Scaling rule in SFC. II. A practical rule for isocratic systems

Area of Science:

• Chromatography
• Supercritical Fluid Chromatography (SFC)
• Chemical Engineering

Background:

• Scaling methods are crucial in chromatography for transferring methods between analytical and preparative systems.
• Unlike liquid chromatography, SFC lacks established geometric rules or principles for scaling.
• Previous attempts proposed maintaining average density, but this is limited by data availability.

Purpose of the Study:

• To address the lack of scaling principles in SFC.
• To investigate a simpler and more practical approach for SFC scaling.
• To evaluate the applicability of matching average pressures for SFC method transfer.

Main Methods:

• The study evaluated scaling approaches for supercritical fluid chromatography.
• Comparison of maintaining average density versus matching average pressures.
• Analysis of scaling across various operating conditions in SFC.

Main Results:

• Matching average pressures is demonstrated as an effective scaling strategy in SFC.
• This method is applicable over a wide range of operating conditions.
• It overcomes the limitations associated with density data availability.

Conclusions:

• Matching average pressures provides a practical and accessible method for scaling SFC systems.
• This approach simplifies the process of transferring methods between analytical and preparative SFC.
• It offers a viable alternative to density-based scaling, enhancing method development efficiency.