Advanced structural neuroimaging in progressive supranuclear palsy: Where do we stand?

Area of Science:

• Neurology
• Neuroimaging
• Pathology

Background:

• Progressive supranuclear palsy (PSP) is a neurodegenerative disease.
• PSP is characterized by supranuclear gaze palsy, postural instability, parkinsonism, and cognitive decline.
• Structural neuroimaging shows variable grey and white matter involvement in PSP.

Purpose of the Study:

• To review advanced structural neuroimaging studies in progressive supranuclear palsy (PSP).
• To analyze in vivo pathological changes in PSP using techniques like VBM, DTI, and MRV.
• To discuss the clinical significance of these neuroimaging findings in PSP.

Main Methods:

• Review of published studies utilizing advanced structural neuroimaging techniques.
• Inclusion of methods such as VBM, DTI, DWI, MRV, shape analysis, cortical thickness analysis, and MR morphometry.
• Focus on in vivo pathological changes in progressive supranuclear palsy (PSP).

Main Results:

• Grey matter (GM) involvement predominantly in the midbrain, thalamus, basal ganglia, and cerebellum.
• Widespread white matter (WM) tract damage reported in progressive supranuclear palsy (PSP).
• Neuroimaging demonstrates variable patterns of brain atrophy in PSP.

Conclusions:

• Advanced structural neuroimaging provides critical insights into the in vivo pathology of PSP.
• Understanding these pathological changes is crucial for diagnosing and managing PSP.
• Further research can correlate imaging findings with clinical progression and treatment strategies for PSP.