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Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
Published on: April 21, 2016
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The bioink: A comprehensive review on bioprintable materials
Monika Hospodiuk1, Madhuri Dey2, Donna Sosnoski1
1Engineering Science and Mechanics Department, Penn State University, University Park, PA 16802, USA; The Huck Institutes of the Life Sciences, Penn State University, University Park, PA 16802, USA.
Biotechnology Advances
|January 7, 2017
Summary
This review comprehensively analyzes bioinks, essential materials for 3D bioprinting tissues and organs. It compares various bioink types, detailing their properties and applications for advancing regenerative medicine.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Three-dimensional (3D) bioprinting utilizes bioinks to fabricate living tissues and organs.
- Bioinks are critical materials that enable the precise deposition of cells and biologics.
- Advancements in bioinks are crucial for the success of tissue engineering and regenerative medicine.
Purpose of the Study:
- To provide the first comprehensive review of existing bioink types.
- To compare different bioink materials based on numerous critical parameters.
- To discuss current limitations and future prospects of bioinks in bioprinting.
Main Methods:
- Review of hydrogels, cell aggregates, microcarriers, and decellularized matrix components.
- Analysis of bioinks used in extrusion-, droplet-, and laser-based bioprinting processes.
- Detailed comparison across multiple criteria including bioprintability, cell viability, biomimicry, and mechanical integrity.
Main Results:
- Identified and categorized various bioink types and their suitability for different bioprinting modalities.
- Evaluated bioinks based on cell viability, proliferation, biomimicry, resolution, and cost-effectiveness.
- Assessed bioinks for mechanical properties, degradation, immune compatibility, and commercial availability.
Conclusions:
- Bioink selection significantly impacts the success of 3D bioprinting for tissue and organ fabrication.
- Current bioink limitations require further research and development for clinical translation.
- Future prospects involve optimizing bioinks for enhanced functionality, scalability, and broader applications in regenerative medicine.
