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Annexin A6-A multifunctional scaffold in cell motility
Thomas Grewal1, Monira Hoque1, James R W Conway2
1a Faculty of Pharmacy , University of Sydney , Sydney , NSW , Australia.
Cell Adhesion & Migration
|January 7, 2017
Summary
Annexin A6 (AnxA6) is a calcium-dependent scaffold protein. This review explores its roles in cell migration, membrane transport, and signaling, highlighting its involvement in cancer progression.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Annexin A6 (AnxA6) is a calcium-dependent phospholipid-binding protein.
- AnxA6 localizes to the plasma membrane and endosomal compartments.
- It functions as a scaffold protein, influencing signaling, cholesterol, and membrane transport.
Purpose of the Study:
- To review the multifaceted roles of Annexin A6 (AnxA6).
- To discuss AnxA6's function as a scaffold protein in cellular processes.
- To examine AnxA6's involvement in cell migration and cancer.
Main Methods:
- Immunohistochemistry
- Subcellular fractionation
- Live cell microscopy
Main Results:
- AnxA6 is predominantly found at the plasma membrane and endosomal compartments.
- AnxA6 modulates cholesterol and membrane transport and influences actin dynamics.
- AnxA6 is implicated in cell proliferation, survival, differentiation, inflammation, membrane repair, and viral infection.
Conclusions:
- AnxA6's scaffold functions are critical for modulating cell migration in health and disease.
- AnxA6 plays a significant role in cancer cell migration and invasion.
- Further research into AnxA6's mechanisms can reveal therapeutic targets.
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