Effects of infant formula supplemented with prebiotics compared with synbiotics on growth up to the age of 12 mo: a

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Hania Szajewska1, Marek Ruszczyński1, Henryk Szymański2

  • 1Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland.

Pediatric Research
|January 7, 2017
PubMed

Insights

Infant formula supplemented with synbiotics, containing prebiotics (fructooligosaccharides and galactooligosaccharides) and Lactobacillus paracasei, demonstrated safety for infant growth. Synbiotics showed a potential, though uncertain, reduction in respiratory infections compared to prebiotics alone.

Area of Science:

  • Pediatric Nutrition
  • Microbiome Research
  • Infant Health

Background:

  • Growth is a key indicator for infant formula (IF) safety.
  • Investigated IF with prebiotics (FOS/GOS) versus synbiotics (FOS/GOS + L. paracasei F19).

Purpose of the Study:

  • To assess the impact of synbiotic-supplemented IF on healthy infant growth.
  • To compare growth outcomes between prebiotic- and synbiotic-supplemented IF.

Main Methods:

  • 182 healthy, full-term infants were randomized at 28 days of age.
  • Infants received either prebiotic- or synbiotic-supplemented IF until 6 months of age.
  • Growth and safety parameters were monitored through 12 months.

Main Results:

  • No significant differences in anthropometric parameters between groups up to 12 months.
  • Synbiotic group showed a potential reduction in lower respiratory tract infections, but with wide confidence intervals.
  • No serious adverse events were reported in either group.

Conclusions:

  • Synbiotic-supplemented IF is safe for infant growth, with no significant differences compared to prebiotic-supplemented IF.
  • Further research is needed to confirm the effect of synbiotics on lower respiratory tract infections.
Abstract

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