Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

2.7K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.7K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

1.6K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analyzing Transmembrane Protein and Hydrophobic Helix Topography by Dual Fluorescence Quenching.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Thermodynamic analysis of destabilization of myoglobin by fatty acid ionic liquids.

Archives of biochemistry and biophysics·2026
Same author

Hierarchically Restructured Antibacterial Electrodes for Neural Interfaces: Electrochemical and Microstructural Evolution under Extended Cycling.

ACS applied materials & interfaces·2026
Same author

3D in vitro co-culture disc for assessing cancer invasiveness in the tumor stroma microenvironment.

In vitro models·2026
Same author

Combinatorial Antimicrobial Effects of Imidazolium-Based Ionic Liquids and Antifungals on Model Fungal Organisms.

Biomolecules·2025
Same author

Silver (I) and Silver (II) Oxide Films for Biomedical Implants: Synthesis, Stability, Ion Release, and Antibacterial Efficacy.

Journal of biomedical materials research. Part A·2025

Related Experiment Video

Updated: Mar 9, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

25.2K

A Cationic Amphiphilic Random Copolymer with pH-Responsive Activity against Methicillin-Resistant Staphylococcus

Sungyoup Hong1, Haruko Takahashi2, Enrico T Nadres2

  • 1Department of Emergency Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Plos One
|January 7, 2017
PubMed
Summary

A new cationic polymer shows pH-dependent antimicrobial activity against drug-resistant Staphylococcus aureus. This pH-sensitive agent selectively targets bacteria at neutral pH, offering a potential strategy for treating skin infections.

More Related Videos

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

14.7K
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

4.1K

Related Experiment Videos

Last Updated: Mar 9, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

25.2K
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

14.7K
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
11:52

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

4.1K

Area of Science:

  • Biochemistry
  • Materials Science
  • Microbiology

Background:

  • Drug-resistant Staphylococcus aureus poses a significant threat to public health.
  • Developing novel antimicrobial agents is crucial for combating infections.
  • Cationic, amphiphilic polymers show promise as antimicrobial agents.

Purpose of the Study:

  • To investigate the pH-dependent antimicrobial activity of a novel cationic, amphiphilic random copolymer.
  • To evaluate the polymer's efficacy against clinical isolates of drug-resistant Staphylococcus aureus.
  • To assess the polymer's safety profile regarding human cells.

Main Methods:

  • In vitro antimicrobial assays were performed against clinical isolates of methicillin-resistant and vancomycin-intermediate S. aureus.
  • The polymer's activity was tested at different pH values (acidic and neutral).
  • Hemolytic activity and cytotoxicity assays were conducted using human red blood cells and dermal fibroblasts.

Main Results:

  • The cationic polymer demonstrated pH-dependent bactericidal activity against S. aureus.
  • Antimicrobial activity was observed at neutral pH but was lost under acidic conditions.
  • The polymer exhibited no significant hemolytic activity or cytotoxicity towards human cells across a pH range of 5.5-7.4.

Conclusions:

  • The developed cationic polymer is a selective antimicrobial agent effective against drug-resistant S. aureus.
  • Its pH-dependent activity suggests potential for targeted therapy in skin infections.
  • The polymer's safety profile indicates a favorable therapeutic window for potential clinical applications.