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Fatigue in epilepsy: A systematic review and meta-analysis
Oh-Young Kwon1, Hyeong Sik Ahn2, Hyun Jung Kim2
1Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
Seizure
|January 8, 2017
Summary
Fatigue is a common issue for epilepsy patients, affecting nearly half of them. Depression is a significant risk factor and is closely linked to experiencing fatigue.
Area of Science:
- Neurology
- Psychiatry
- Clinical Research
Background:
- Epilepsy is a chronic neurological disorder.
- Fatigue is a frequently reported symptom in epilepsy patients.
- Understanding the prevalence and contributing factors of fatigue is crucial for patient management.
Purpose of the Study:
- To determine the frequency and severity of fatigue in individuals with epilepsy.
- To identify risk factors associated with fatigue in epilepsy.
- To explore the relationship between depression and fatigue in this population.
Main Methods:
- A systematic literature search was conducted across major databases (MEDLINE, EMBASE, COCHRANE, Web of Science, SCOPUS).
- Included studies were original research articles reporting fatigue data in adult epilepsy patients.
- Fatigue strength was assessed using standardized inventories, and frequency was based on reported events.
Main Results:
- 12 studies involving 700 epilepsy patients were included.
- The overall frequency of fatigue was 47.1%.
- Depression, sleep impairment, and poor sleep quality were identified as key risk factors for fatigue.
Conclusions:
- Fatigue is a prevalent symptom in epilepsy patients.
- A significant correlation exists between depression and fatigue.
- Managing fatigue and its risk factors, particularly depression, is essential for comprehensive epilepsy care.
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