[Comparative characterization of the hepatotoxicity of isoniazid, rifampicin and pyrazinamide]

In experiments of rats it was established that administration of isoniazid and rifampicin in equimolecular doses (50 and 250 mg/kg) for 14 days increased the activities of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in the serum, enhanced lipid peroxidation in hepatocytic membranes, caused significant disturbances of bile excretion. Pyrazinamide administered in an equimolecular dose (45 mg/kg) moderately suppresses bile excretion and exerts no effect on the activity of the liver enzymes in the serum and the level of lipid peroxidation.