CDPKs and 14-3-3 Proteins: Emerging Duo in Signaling

Calcium-dependent protein kinases (CDPKs) are Ca²⁺-sensors that play pivotal roles in plant development and stress responses. They have the unique ability to directly translate intracellular Ca²⁺ signals into reversible phosphorylation events of diverse substrates which can mediate interactions with 14-3-3 proteins to modulate protein functions. Recent studies have revealed roles for the coordinated action of CDPKs and 14-3-3s in regulating diverse aspects of plant biology including metabolism, development, and stress responses. We review here the underlying interaction and cross-regulation of the two signaling proteins, and we discuss how this insight has led to the emerging concept of CDPK/14-3-3 signaling modules that could contribute to response specificity.