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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
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Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
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Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
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Related Experiment Video

Updated: Mar 9, 2026

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

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T Cell Trafficking through Lymphatic Vessels.

Morgan C Hunter1, Alvaro Teijeira2, Cornelia Halin1

  • 1Institute of Pharmaceutical Sciences, ETH Zurich , Zurich , Switzerland.

Frontiers in Immunology
|January 10, 2017
PubMed
Summary
This summary is machine-generated.

T cell migration relies on lymphatic vessels (LVs) for rapid long-distance travel. This review details how lymphatic anatomy and molecular factors facilitate T cell trafficking through LVs, crucial for adaptive immunity.

Keywords:
T cellsafferentefferentlymph nodelymphatic vesselsmigrationtrafficking

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Related Experiment Videos

Last Updated: Mar 9, 2026

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

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Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration
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Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration

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Area of Science:

  • Immunology
  • Cell Biology
  • Vascular Biology

Background:

  • T cell migration is vital for adaptive immunity, utilizing blood and lymphatic vessels for transport.
  • Mechanisms of T cell egress from blood vessels are well-studied, but lymphatic vessel T cell trafficking is less understood.
  • Lymphatic vessels facilitate T cell recirculation within lymph nodes and tissue exit/entry via afferent and efferent lymphatics.

Conclusions:

  • The lymphatic system's anatomy is intrinsically suited to support efficient T cell trafficking.
  • Further research into the molecular intricacies of T cell-lymphatic vessel interactions is warranted.
  • Understanding T cell migration through lymphatics is key to advancing adaptive immunity research and therapeutic strategies.