Related Experiment Video
Updated: Mar 9, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
Published on: February 27, 2016
The seven faces of SIRT7
Maximilian F Blank1, Ingrid Grummt1
1a Molecular Biology of the Cell II , German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance , Heidelberg , Germany.
Abstract:
SIRT7, a member of the sirtuin family of NAD+-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress resistance, aging and tumorigenesis. Despite this important functional link, the enzymatic activity, the molecular targets and physiological functions of SIRT7 are poorly defined. Here, we review recent progress in SIRT7 research and elaborate the main pathways in which SIRT7 participates.
Related Concept Videos
Regulation of the Unfolded Protein Response
PI3K/mTOR/AKT Signaling Pathway
Protein Modifications in the RER
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
Protein Complexes with Interchangeable Parts
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
Replicative Cell Senescence
The Unfolded Protein Response
