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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
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Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions
Thomas J Anchordoquy, Yechezkel Barenholz1, Diana Boraschi2
1Laboratory of Membrane and Liposome Research, IMRIC, The Hebrew University-Hadassah Medical School , Jerusalem 91120, Israel.
ACS Nano
|January 10, 2017
Summary
Engineered nanoparticles show promise for cancer treatment and imaging. Overcoming biological, immunological, and translational barriers is crucial for advancing nanomedicine applications in clinical settings.
Area of Science:
- Nanomedicine
- Biotechnology
- Cancer Research
Background:
- Engineered nanoparticles have advanced cancer imaging and treatment, with candidates in clinical trials.
- Clinical translation of nanoparticle-based agents faces significant biological, immunological, and translational hurdles.
Framework:
- A workshop focused on mechanisms and barriers in nanomedicine to identify key challenges.
- Discussion centered on biological, toxicological, immunological, and translational aspects of nanomedicine.
Implementation:
- Addressing these barriers requires open dialogue within the nanomedicine community.
- Identifying and overcoming limitations is essential for qualitative leaps in nanomedicine translation.
Implications:
- This discussion highlights critical issues for the future of cancer nanomedicine.
- Strategies to overcome barriers are needed to realize the full potential of nanotherapeutics and nano-imaging agents.
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