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Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
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Enzymes02:34

Enzymes

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Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
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In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
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Enzyme-Based Strategies for Structuring Foods for Improved Functionality.

Benjamin Zeeb1, David Julian McClements2, Jochen Weiss1

  • 1Department of Food Physics and Meat Science, Institute of Food Science and Biotechnology, University of Hohenheim, 70599 Stuttgart, Germany;

Annual Review of Food Science and Technology
|January 10, 2017
PubMed
Summary
This summary is machine-generated.

Enzyme technologies offer sustainable food structuring. Enzymes modify food dispersions

Keywords:
bioconjunctionbiopolymerscross-linkingdegradingenzymes

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Area of Science:

  • Food Science and Technology
  • Biotechnology
  • Materials Science

Background:

  • Enzyme technologies are gaining traction for creating novel food dispersions.
  • Enzymes offer an eco-friendly alternative to chemical agents for food structuring.
  • Focus is on enzymes acting on proteins and polysaccharides.

Purpose of the Study:

  • To review recent advancements in using enzymes for food structure modification.
  • To highlight the impact of enzymes on interfacial and bulk properties of food dispersions.
  • To emphasize commercially available enzymes for food applications.

Main Methods:

  • Review of scientific literature on enzyme applications in food structuring.
  • Analysis of how cross-linking enzymes (transglutaminase, laccase) form biopolymer bonds.
  • Examination of how degrading enzymes (proteases) induce protein self-assembly.

Main Results:

  • Enzymes can improve stability, functionality, and texture of food dispersions.
  • Cross-linking enzymes enhance biopolymer networks.
  • Degrading enzymes facilitate the formation of ordered colloidal structures.

Conclusions:

  • Enzyme technology provides a bio-inspired approach for food structure design.
  • Strategic use of enzymes can lead to enhanced physical, functional, textural, and optical properties.
  • Enzymatic modification offers a sustainable and effective method for food manufacturers.