[Hemostasis and homeostasis]

It has been established as a result of experimental and clinical studies that the phase of hypercoagulation of the DIC syndrome is marked by an appreciable increase of noradrenaline content in blood and tissues whereas the phase of hypocoagulation by a considerable diminution of the substance in blood and tissues. During hypercoagulation of the DIC syndrome, the function of mast cells in the animals' tissues rises. On the contrary, administration of heparin reduces the noradrenaline content in tissues to a considerable degree. All the four prostaglandin groups (A2, B2, F2 and E2) alter the function of the tissue component within the system of regulation of the aggregate state of the blood. At the same time their effect is determined by the specificity of the respective prostaglandin, by exposure, and by the character of the metabolism of the respective tissues. The data obtained provide new evidence in favour of the author's conception that hemostasis is a private case of homeostasis both as regards the biological significance of the process and its common character with respect to the neuroendocrine forms of regulation.