Related Experiment Video
Updated: Mar 9, 2026
04:20
Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats
Published on: March 28, 2025
653
Risk factors for severe postpartum hemorrhage: a case-control study.
Lill Trine Nyfløt1,2,3, Irene Sandven4, Babill Stray-Pedersen5
1Division of Gynecology and Obstetrics, Oslo University Hospital, Rikshospitalet, P.O.box 4950, Nydalen, 0424, Oslo, Norway. l.t.nyflot@medisin.uio.no.
BMC Pregnancy and Childbirth
|January 11, 2017
Summary
Women with a history of severe postpartum hemorrhage (PPH) face the highest risk of recurrence. Identifying key risk factors is crucial for developing better prediction models and improving maternal health outcomes.
Area of Science:
- Obstetrics and Gynecology
- Maternal Health
- Epidemiology
Background:
- Severe postpartum hemorrhage (PPH) incidence is rising in high-income nations.
- Severe PPH is a significant cause of maternal morbidity.
- Limited research exists on contemporary risk factors for severe PPH.
Purpose of the Study:
- To identify independent risk factors for severe PPH.
- To analyze a contemporary obstetric cohort in Norway.
- To inform the development of PPH prediction models.
Main Methods:
- Case-control study design.
- Inclusion of 43,105 deliveries between 2008-2011.
- Logistic regression analysis to identify risk factors.
Main Results:
- Severe PPH occurred in 2.5% of deliveries.
- Uterine atony (60%) and placental complications (36%) were primary causes.
- Strongest risk factors included prior severe PPH, anticoagulant use, anemia, pre-eclampsia/HELLP, fibromas, multiple pregnancy, and ART.
Conclusions:
- A history of severe PPH is the strongest predictor of recurrence.
- Established clinical risk factors should be integrated into PPH prediction models.
- Prior severe PPH should be a key factor in PPH risk assessment.
