Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

110
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
110
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

390
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
390
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

62
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
62
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

79
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
79
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

67
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
67
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

136
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
136

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A simple radioassay for detection of antithyroglobulin autoantibodies.

The Indian journal of medical research·1992
Same author

An immunoradiometric assay for measurement of serum thyroglobulin.

The Indian journal of medical research·1992
Same author

Modification of radiosensitivity by the so-called tissue recovery stimulator. I. Radiosensitizing effects of solcoseryl.

Journal of radiation research·1992
Same author

Postnatal laminar development of cholinergic receptors, protein kinase C and dihydropyridine-sensitive calcium antagonist binding in rat visual cortex. Effect of visual deprivation.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·1992
Same author

Cerebral glucose metabolic rates after 30 and 45 minute acquisitions: a comparative study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1992
Same author

Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography.

Analytical biochemistry·1992
Same journal

Lipid digestion- driven drug fate as a key determinant of SNEDDS performance: Mechanistic basis of absorption and in vitro- in vivo disconnect.

International journal of pharmaceutics·2026
Same journal

Redox-responsive nanomedicine beyond glutathione: harnessing reactive oxygen species and emerging endogenous triggers for precision drug delivery.

International journal of pharmaceutics·2026
Same journal

Preventing tablet defects through vacuum-assisted deaeration of a powder bed.

International journal of pharmaceutics·2026
Same journal

Approaches for enhancing bioavailability of macromolecular drugs.

International journal of pharmaceutics·2026
Same journal

Characteristics of asymmetric microcrystalline solidification pellets and a better prediction for bioequiavailability based on solubility-permeability theory.

International journal of pharmaceutics·2026
Same journal

A CFPD-FSI analysis of the impact of nasal hairs on airflow patterns, nasal resistance, and particle filtration in a realistic human nasal airway.

International journal of pharmaceutics·2026
See all related articles

Related Experiment Video

Updated: Mar 9, 2026

A Microfluidic Platform for Stimulating Chondrocytes with Dynamic Compression
07:23

A Microfluidic Platform for Stimulating Chondrocytes with Dynamic Compression

Published on: September 13, 2019

7.2K

Continuous direct compression as manufacturing platform for sustained release tablets.

B Van Snick1, J Holman2, C Cunningham3

  • 1Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.

International Journal of Pharmaceutics
|January 11, 2017
PubMed
Summary
This summary is machine-generated.

Developing sustained release tablets using continuous direct compression is feasible. Directly compressible excipients significantly improve process robustness and product quality compared to standard grades, especially for challenging formulations.

Keywords:
Continuous direct compressionContinuous manufacturingContinuous mixingProcess analytical technologyRaw material propertiesSustained releaseTwin screw feeding

More Related Videos

Microfabricated Platforms for Mechanically Dynamic Cell Culture
15:21

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

14.2K
Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers
09:44

Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers

Published on: July 7, 2023

5.2K

Related Experiment Videos

Last Updated: Mar 9, 2026

A Microfluidic Platform for Stimulating Chondrocytes with Dynamic Compression
07:23

A Microfluidic Platform for Stimulating Chondrocytes with Dynamic Compression

Published on: September 13, 2019

7.2K
Microfabricated Platforms for Mechanically Dynamic Cell Culture
15:21

Microfabricated Platforms for Mechanically Dynamic Cell Culture

Published on: December 26, 2010

14.2K
Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers
09:44

Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers

Published on: July 7, 2023

5.2K

Area of Science:

  • Pharmaceutical Manufacturing
  • Materials Science
  • Chemical Engineering

Background:

  • Continuous direct compression offers advantages for pharmaceutical manufacturing.
  • Developing robust sustained release formulations with challenging excipients is complex.
  • Material properties like flowability and density significantly impact process performance.

Purpose of the Study:

  • To establish a framework for process and product development in continuous direct compression.
  • To evaluate the performance of standard versus directly compressible hydroxypropyl methylcellulose (HPMC) grades.
  • To optimize continuous manufacturing of sustained release tablets with challenging formulations.

Main Methods:

  • Investigated feeding behavior using feed factor profiles and density.
  • Utilized inline near-infrared spectroscopy (NIRs) for residence time distribution (RTD) and blend uniformity.
  • Assessed tablet content/weight variability, tabletability, and dissolution profiles.

Main Results:

  • Directly compressible Methocel DC2 significantly improved tablet quality and process robustness over standard Methocel CR.
  • Material density strongly influenced feeder settings; flowability is critical for continuous blending and die-filling.
  • Optimizing axial mixing for Methocel CR did not guarantee tablet quality; controlling thickness is crucial for dissolution.

Conclusions:

  • Reformulating with directly compressible excipients enhances continuous manufacturing of sustained release tablets.
  • Material flowability is a key factor for robust continuous blending and die-filling processes.
  • Balancing process parameters and material attributes is essential for reproducible tablet quality and dissolution.