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Updated: Mar 9, 2026
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
Fibrous Dysplasia Mimicking Malignancy on 68Ga-DOTATATE PET/CT
Georgios Z Papadakis1, Corina Millo, Samira M Sadowski
1From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, †PET Department; Clinical Center, and ‡Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; §Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland; ∥Department of Radiology, Medical School, University of Crete, Greece; and ¶Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida, Orlando, FL.
Abstract:
Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of Ga-DOTATATE-avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.
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