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Resveratrol suppresses human hepatocellular carcinoma via targeting HGF-c-Met signaling pathway

Feng Gao1, Gang Deng2, Wenbin Liu3

  • 1Department of Ultrasonography, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China.

Oncology Reports
|January 12, 2017
PubMed

Insights

Resveratrol, a compound in red wine, shows significant antitumor effects against hepatocellular carcinoma (HCC) by inhibiting the HGF-c-Met pathway. This research highlights c-Met as a potential therapeutic target for HCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Resveratrol, a polyphenol from red wine, is investigated for its potential anticancer properties.
  • Hepatocellular carcinoma (HCC) is a major global health concern with limited effective treatments.
  • The HGF-c-Met signaling pathway is implicated in HCC progression and metastasis.

Purpose of the Study:

  • To investigate the antitumor effects of resveratrol on human hepatocellular carcinoma (HCC) cells.
  • To elucidate the role of the HGF-c-Met signaling pathway in resveratrol's anti-HCC activity.
  • To evaluate resveratrol's therapeutic potential in preclinical HCC models.

Main Methods:

  • Cell culture of human HCC cells.
  • Assessment of resveratrol's effects on cell growth (anchorage-dependent and -independent).
  • Analysis of HGF-c-Met signaling pathway activation and c-Met expression.
  • In vitro invasion assays and c-Met knockdown experiments.
  • In vivo studies using a xenograft mouse model.

Main Results:

  • Resveratrol inhibited HCC cell growth in a dose-dependent manner.
  • Resveratrol down-regulated HGF-induced c-Met signaling and reduced cell membrane c-Met expression.
  • Resveratrol suppressed HGF-induced HCC cell invasion.
  • Knockdown of c-Met reduced HCC cell sensitivity to resveratrol.
  • Resveratrol demonstrated significant antitumor activity in a xenograft model.

Conclusions:

  • Resveratrol exhibits potent antitumor effects against hepatocellular carcinoma.
  • The HGF-c-Met signaling pathway is a key mediator of resveratrol's anti-HCC activity.
  • Targeting the c-Met pathway with resveratrol presents a promising strategy for HCC management.

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