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Antisperm antibodies and sperm motility: a study using timed exposure photomicrography
A J Adeghe1, J Zhang, J Cuthbert
1Department of Obstetrics & Gynaecology, University of Birmingham, U.K.
International Journal of Andrology
|August 1, 1989
Summary
Antisperm antibodies in seminal plasma did not significantly impact sperm motility or movement characteristics. These findings challenge the common belief that these antibodies cause poor sperm motility.
Area of Science:
- Reproductive immunology
- Spermatozoa physiology
Background:
- Antisperm antibodies (ASA) are implicated in infertility.
- Their direct impact on sperm motility remains debated.
Purpose of the Study:
- To investigate the association between ASA and sperm movement characteristics.
- To determine if ASA cause poor sperm motility.
Main Methods:
- Passive transfer of ASA from seminal plasma to normal donor sperm.
- Analysis of sperm motility parameters (velocity, progressive motility) using photomicrography.
Main Results:
- No significant correlation found between ASA titre and sperm movement characteristics.
- No difference in motility between samples with agglutinating versus immobilizing ASA activity.
Conclusions:
- Current findings do not support ASA as a cause of reduced sperm motility.
- Further research may be needed to clarify the role of ASA in male infertility.