Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Public reporting guidelines for outbreak data: Enabling accountability for effective outbreak response by developing standards for transparency and uniformity.

Public health·2025
Same author

Single-Flux-Quantum Multiplier Circuits for Synthesizing Gigahertz Waveforms With Quantum-Based Accuracy.

IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee·2024
Same author

EXPERIMENTAL MANIPULATION OF ALTERNATIVE PATHWAYS OF DIFFERENTIATION IN CULTURES OF EMBRYONIC CHICK NEURAL RETINA.

Development, growth & differentiation·2023
Same author

COMPARISON OF THE GROWTH AND DIFFERENTIATION OF EPITHELIAL CELLS FROM NORMAL AND HYPERPLASTIC LENSES OF THE CHICK: STUDIES OF IN VITRO CELL CULTURES.

Development, growth & differentiation·2023
Same author

THE INFLUENCE OF GROWTH-INHIBITING AND GROWTH-PROMOTING MEDIUM CONDITIONS ON CRYSTALLIN ACCUMULATION IN TRANSDIFFERENTIATING CULTURES OF EMBRYONIC CHICK NEURAL RETINA.

Development, growth & differentiation·2023
Same author

DIFFERENTIATION AND TRANSDIFFERENTIATION IN VITRO OF NEURAL RETINA FROM MUTANT CHICKENS WITH HYPERPLASIC LENS EPITHELIUM

Development, growth & differentiation·2023

Related Experiment Video

Updated: Jul 28, 2026

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
13:56

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Published on: November 28, 2012

Skin disease and age-related cataract

C I Phillips1, C A Donnelly, R M Clayton

  • 1Department of Surgery, University of Edinburgh, U.K.

Acta Dermato-Venereologica
|July 1, 1996
PubMed
Summary

Age-related cataract is linked to skin conditions and treatments. Hydrocortisone use, particularly after age 69, shows a strong association with cataract development, even after accounting for other skin issues.

Area of Science:

  • Ophthalmology
  • Dermatology
  • Clinical Epidemiology

Background:

  • Age-related cataract is a leading cause of vision impairment.
  • Dermatological conditions are common, especially in older adults.
  • The relationship between dermatological issues and cataract is not fully understood.

Purpose of the Study:

  • To investigate the association between dermatological abnormalities and treatments with age-related cataract.
  • To identify specific dermatological factors or treatments that may increase cataract risk.

Main Methods:

  • A case-control study involving 1000 cataract patients and 1000 matched controls.
  • Controls were matched for gender, age (within 5-year bands), and family doctor.
  • Data collected via venepuncture, eye examinations, and questionnaires.

More Related Videos

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Related Experiment Videos

Last Updated: Jul 28, 2026

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
13:56

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Published on: November 28, 2012

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Main Results:

  • A significant association was found between age-related cataract and dermatological abnormalities.
  • This association was more pronounced in individuals over 69 years of age.
  • Hydrocortisone use, especially after age 69, demonstrated a strong, independent association with cataract, even after adjusting for dermatological conditions.

Conclusions:

  • Dermatological abnormalities and their treatments are significantly associated with age-related cataract.
  • Hydrocortisone use is particularly implicated as a risk factor for cataract, independent of other dermatological conditions.
  • Further research into the specific mechanisms linking hydrocortisone to cataract is warranted.