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Leucocyte rheology in controlled coronary ischaemia
G Ciuffetti1, G Bellomo, M Mercuri
12nd Department of Internal Medicine, University of Perugia, Italy.
International Journal of Cardiology
|November 1, 1989
Summary
Early ischemia in coronary artery disease alters white blood cell rheology. Polymorphonuclear leucocyte filterability significantly increased in patients post-exercise, indicating a potential early marker for ischemia.
Area of Science:
- Cardiovascular Physiology
- Hematology
Background:
- Early detection of ischemia in coronary artery disease is crucial.
- White blood cell (leukocyte) rheology changes may indicate early ischemic events.
Purpose of the Study:
- To investigate alterations in white blood cell rheology during early stages of controlled ischemia in coronary arterial disease.
- To assess polymorphonuclear leucocyte (PMN) filterability and activation in patients with stable angina pectoris.
Main Methods:
- A cycle ergometer test was used to induce controlled ischemia.
- Blood samples were analyzed before, during, and after exercise in 18 patients and 22 controls.
- Polymorphonuclear leucocyte filterability and activation were measured.
Main Results:
- Leukocyte count increased post-exercise in both patients and controls.
- A significant increase in polymorphonuclear leucocyte filterability was observed in patients compared to rest and controls.
- This enhanced filterability persisted into the recovery period.
Conclusions:
- Increased polymorphonuclear leucocyte filterability may be an early indicator of ischemia in coronary artery disease.
- Leukocyte rheology changes could serve as a novel biomarker for early ischemic detection.