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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

72.2K

High predictability of impaired glucose tolerance by combining cardiometabolic screening parameters in obese children

Cornelis Jan de Groot, Jeroen van der Grond, Yosine Delgado

    Journal of Pediatric Endocrinology & Metabolism : JPEM
    |January 12, 2017
    PubMed

    Insights

    Screening overweight children for impaired glucose tolerance (IGT) can be improved. Elevated blood pressure and liver enzymes are key indicators, increasing the predictability of IGT in pediatric populations.

    Area of Science:

    • Pediatrics
    • Endocrinology
    • Metabolic Disorders

    Background:

    • Debate exists on optimal screening criteria for impaired glucose tolerance (IGT) in overweight and obese children.
    • Oral glucose tolerance testing (OGTT) is used for diagnosis, but identifying high-risk individuals is crucial.

    Purpose of the Study:

    • To identify risk factors that predict the presence of IGT in overweight children.
    • To evaluate the effectiveness of combining screening parameters for improved IGT detection.

    Main Methods:

    • A cohort of overweight children undergoing OGTT was analyzed.
    • Association of anthropometric and laboratory parameters with IGT was determined.
    • The sensitivity of screening for IGT using combined parameters was assessed.

    Main Results:

    • Out of 145 children, 11 had IGT, with two also having impaired fasting glucose (IFG).
    • Elevated blood pressure (p=0.025) and elevated liver enzymes (p=0.003) were significantly associated with IGT.
    • Screening based on elevated blood pressure or liver enzymes achieved a sensitivity of 1.00 for IGT detection.

    Conclusions:

    • Screening overweight children with elevated blood pressure or elevated liver enzymes significantly enhances IGT predictability.
    • Combining these parameters improves IGT screening compared to using IFG alone.
    • This approach offers a more sensitive method for identifying children at risk for IGT.
    Abstract

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