Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

1.1K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.1K
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.6K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.6K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

1.1K
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
1.1K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

1.7K
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydrocephalus-associated persistent pain: a preclinical investigation correlating brain fluid imbalance and sensory alterations.

Fluids and barriers of the CNS·2026
Same author

Enhanced detection of subtle cortical abnormalities in focal epilepsy using 7 T MRI surface-based models and graph neural networks.

Neuroradiology·2026
Same author

Perineuronal net abnormalities in epileptic human tissue.

Epilepsia·2026
Same author

Clinical utility of [<sup>18</sup>F]-FET PET Imaging in pediatric brain tumors: a case series.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same author

Structural features of the hippocampus covary with memory-guided attention depending on the side of hippocampal sclerosis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Slow-Wave Sleep Fragmentation in Disorders of Arousal and Sleep-Related Hypermotor Epilepsy: A Multicenter Polysomnographic Study.

Neurology·2026

Related Experiment Video

Updated: Mar 9, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

2.8K

Unilobar surgery for symptomatic epileptic spasms.

Carmen Barba1, Roberto Mai2, Laura Grisotto3

  • 1Neuroscience Department Children's Hospital Anna Meyer-University of Florence Florence Italy.

Annals of Clinical and Translational Neurology
|January 13, 2017
PubMed
Summary
This summary is machine-generated.

Complete resection of the seizure onset zone and visible lesions improves outcomes for children with epileptic spasms. Early surgery is recommended to avoid longer epilepsy duration and unfavorable results.

More Related Videos

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.7K
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.7K

Related Experiment Videos

Last Updated: Mar 9, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

2.8K
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.7K
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.7K

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Neurosurgery

Background:

  • Epileptic spasms in children often stem from underlying structural abnormalities.
  • Understanding the pathophysiology and surgical outcomes is crucial for effective treatment.

Purpose of the Study:

  • To identify factors predicting favorable seizure outcomes after surgery for symptomatic epileptic spasms.
  • To enhance the understanding of the pathophysiology of this seizure type.

Main Methods:

  • Retrospective study of 80 children (6 months–15 years) with active epileptic spasms and >1 year follow-up.
  • Analysis included MRI findings, invasive recordings, and surgical resection extent.
  • Multivariate logistic regression was used to assess outcome predictors.

Main Results:

  • 96.3% of patients had MRI-detected structural abnormalities; 72.5% underwent unilobar resections.
  • 61.3% achieved favorable seizure control (Engel class I).
  • Complete resection of the seizure onset zone and visible lesions significantly predicted favorable outcomes (Engel class IA). Older age at surgery, indicating longer epilepsy duration, was associated with unfavorable outcomes.

Conclusions:

  • Focal cortical origin of spasms is supported by surgical outcomes and invasive recordings.
  • Surgery for spasms originating from discrete lesions should follow principles of focal epilepsy surgery, prioritizing unilobar, one-stage resections.