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Updated: Mar 8, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
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Relationship Between Abnormalities on High-Resolution Computerized Tomography, Pulmonary Function, and
Gulfidan Cakmak1, Tuba Selcuk Can, Sule Gundogdu
1Istanbul Haseki Education and Research Hospital,. gulfidan70@gmail.com.
Summary
High-resolution CT (HRCT) lung abnormalities in progressive systemic sclerosis (pSS) correlate with disease duration and severity. Increased neutrophils in bronchoalveolar lavage (BAL) indicate more severe lung fibrosis in SSc-ILD.
Area of Science:
- Pulmonary Medicine
- Radiology
- Rheumatology
Background:
- Progressive systemic sclerosis (pSS) is a multisystemic autoimmune disease.
- Lung fibrosis is a common and serious complication of pSS.
- The relationship between imaging findings, clinical status, and lung inflammation in pSS requires further elucidation.
Purpose of the Study:
- To investigate correlations between high-resolution computed tomography (HRCT) findings and clinical/functional status in pSS patients.
- To explore the relationship between HRCT findings and bronchoalveolar lavage (BAL) results, specifically alveolitis, in pSS.
Main Methods:
- Sixty-five pSS patients underwent thoracic HRCT, pulmonary function tests (PFTs), and BAL.
- HRCT findings were scored using the Warrick et al. method.
- Correlations were analyzed between HRCT scores, PFTs, dyspnea, and BAL parameters (e.g., neutrophil percentage).
Main Results:
- A correlation was observed between the number of subpleural cysts and disease duration.
- HRCT scores correlated with patient age.
- A significant correlation was found between the percentage of neutrophils in BAL fluid and the extent of honeycombing on HRCT.
Conclusions:
- HRCT abnormalities in pSS correlate with pulmonary function parameters like FVC, RV, and DLCO.
- Increased neutrophil percentage in BAL fluid is associated with more extensive honeycombing in SSc-associated interstitial pneumonia (SSc-IP).
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