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Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model
Seokwon Pok1,2, Igor V Stupin3, Christopher Tsao1
1Department of Bioengineering, Rice University, Houston, TX 77005, USA.
Advanced Healthcare Materials
|January 13, 2017
Abstract:
In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch.
