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Programmed dissociation of dimer and trimer origami structures by aptamer-ligand complexes
1Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il itamar.willner@mail.huji.ac.il.
Nanoscale
|January 14, 2017
Abstract:
Dimer- and trimer-origami frames are bridged by duplexes that include caged, sequence-specific, anti-ATP and/or anti-cocaine aptamer sequences. The programmed dissociation of the origami dimers or trimers in the presence of ATP and/or cocaine ligands is demonstrated. The processes are followed by AFM imaging and by electrophoretic experiments.
