Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

790
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
790
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

289
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
289
Smooth Endoplasmic Reticulum01:21

Smooth Endoplasmic Reticulum

8.6K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
8.6K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.3K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.3K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.3K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.3K
Pleiotropy01:33

Pleiotropy

43.7K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risks associated with ventriculomegaly and symptomatic communicating hydrocephalus following stereotactic radiosurgery for vestibular schwannoma.

Journal of neurosurgery·2026
Same author

The Trouble with Trials: Systematic Review and Meta-Analysis of Randomized Controlled Trials Comparing Stereotactic Radiosurgery, Whole Brain Radiotherapy, and Observation for Resected Metastatic Brain Disease.

Cancers·2026
Same author

Prognostic factors for 90-day survival after stereotactic radiosurgery for brain metastasis patients.

Journal of neurosurgery·2026
Same author

Long-term tumor control after Gamma Knife radiosurgery for sporadic vestibular schwannoma.

Journal of neurosurgery·2026
Same author

Exploring the Association between Diagnostic and Therapeutic Radiation and the Incidence of Vestibular Schwannoma: A Case-Control Study.

Journal of neurological surgery reports·2025
Same author

Pilot Program in Surgical Anatomy Education for Complex Cranial and Skull Base Procedures: Curriculum Overview and Initial 2-Year Experience at Mayo Clinic.

Journal of neurological surgery. Part B, Skull base·2025

Related Experiment Video

Updated: Mar 8, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.4K

Characterizing and predicting the Nelson-Salassa syndrome.

Christopher S Graffeo1, Avital Perry1, Lucas P Carlstrom1

  • 11Department of Neurologic Surgery, and.

Journal of Neurosurgery
|January 14, 2017
PubMed
Summary

Nelson-Salassa syndrome (NSS) is common after bilateral adrenalectomy for Cushing disease, affecting over 50% of patients. However, most cases are clinically silent, with few requiring treatment.

Keywords:
ACTH = adrenocorticotropin hormoneADX = adrenalectomyCD = Cushing diseaseCushing diseaseEBRT = external-beam radiation therapyNSS = Nelson-Salassa syndromeNelson's syndromeNelson-Salassa syndromeSRS = stereotactic radiosurgeryTSS = transsphenoidal surgerybilateral adrenalectomycorticotropinexternal-beam radiation therapypituitary surgerystereotactic radiosurgerytranssphenoidal surgery

More Related Videos

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.8K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.5K

Related Experiment Videos

Last Updated: Mar 8, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.4K
Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.8K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.5K

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Nelson-Salassa syndrome (NSS) is a rare complication following bilateral adrenalectomy (ADX) for refractory Cushing disease (CD).
  • The classic definition involves rapid, invasive pituitary tumor growth causing hyperpigmentation and visual disturbances.

Purpose of the Study:

  • To evaluate the prevalence and clinical characteristics of NSS in patients with a history of ADX for CD.
  • To identify factors associated with pituitary tumor progression in this cohort.

Main Methods:

  • Retrospective chart review of 88 adult patients with ADX for CD and at least 2 years of follow-up.
  • Analysis included pituitary MRI, clinical data, and statistical comparisons between patients with and without NSS.

Main Results:

  • Over 50% (47/88) of patients developed NSS, characterized by radiographic pituitary disease progression.
  • NSS patients were younger at CD diagnosis and ADX, had larger initial tumors, and were more likely to have received prior radiation therapy.
  • Despite radiographic progression, 68% of NSS patients were asymptomatic, and only 30% required treatment.

Conclusions:

  • NSS is a highly prevalent sequela of ADX for CD, often presenting with asymptomatic radiographic progression.
  • Younger age, larger initial tumor size, and prior radiation therapy are associated with NSS development and potential aggressiveness.
  • The clinical course of NSS is typically indolent, with a minority of patients exhibiting symptomatic or aggressive disease phenotypes.