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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Related Experiment Video

Updated: Mar 8, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

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Clonal cytogenetic abnormalities are predictor in developing non-Hodgkin lymphomas?

Ying Wang1, Yi Xiao1, Xiangyu Meng2

  • 1Department of Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie-Fang Avenue, Wuhan 430030, Hubei, PR China.

Experimental and Molecular Pathology
|January 15, 2017
PubMed
Summary

Clonal cytogenetic abnormalities in lymph nodes may indicate a high risk for developing non-Hodgkin lymphoma, even without initial signs of malignancy. Further follow-up and rebiopsy are crucial for patients with cytogenetic abnormalities but benign morphology.

Area of Science:

  • Hematology
  • Oncology
  • Cytogenetics

Background:

  • Pathological analysis is key for diagnosing malignant lymphoma.
Keywords:
CytogeneticsLymph nodeLymph node pathologyLymphoma

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  • Cytogenetic abnormalities are often unexamined if initial pathological analysis shows no malignancy.
  • Early detection of subtle cytogenetic changes is critical for lymphoma diagnosis.