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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

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Emerging functional roles of nuclear receptors in breast cancer

Tram B Doan1, J Dinny Graham2, Christine L Clarke2

  • 1Westmead Institute for Medical ResearchSydney Medical School - Westmead, University of Sydney, Sydney, New South Wales, Australia tram.doan@sydney.edu.au.

Journal of Molecular Endocrinology
|January 15, 2017
PubMed

Insights

Nuclear receptors (NRs) regulate key processes in breast cancer. Beyond estrogen and progesterone receptors, other NRs are increasingly recognized for their roles in cancer progression, metabolism, and metastasis.

Area of Science:

  • Endocrinology
  • Oncology
  • Genomics

Background:

  • Nuclear receptors (NRs) are crucial regulators of physiological processes and disease.
  • Estrogen and progesterone receptor status is vital for breast cancer prognosis and treatment.
  • Emerging evidence implicates additional NRs in breast cancer initiation and progression.

Purpose of the Study:

  • To review novel insights into NR mechanisms of action.
  • To focus on the emerging roles of NRs in breast cancer biology.
  • To highlight NR involvement in circadian regulation, metabolic reprogramming, and metastasis.

Main Methods:

  • Review of recent scientific literature.
  • Integration of findings from advanced genomic technologies.
  • Focus on functional roles of NRs in breast cancer.

Main Results:

  • Genomic advances provide new understanding of NR mechanisms.
  • Multiple NRs, beyond ER/PR, influence breast cancer.
  • NRs are implicated in circadian rhythm, metabolism, and cancer cell migration/metastasis.

Conclusions:

  • NRs represent a diverse class of regulators in breast cancer.
  • Understanding non-classical NR functions is critical for therapeutic strategies.
  • Targeting NRs offers potential for novel breast cancer treatments.
Keywords:
breast cancercircadian clockmetabolismmigration and metastasisnuclear receptors

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