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Tenofovir-induced nephrotoxicity: A retrospective cohort study
1Sungai Buloh Hospital, Jalan Hospital, 47810, Sungai Buloh, Selangor, Malaysia. chikku.suresh@gmail.com.
The Medical Journal of Malaysia
|January 15, 2017
Summary
Tenofovir (TDF) can cause kidney problems in HIV patients, with an incidence of 12 per 100 person-years. Pre-existing kidney issues, older age, and low CD4 counts increase this risk.
Area of Science:
- HIV/AIDS Research
- Nephrology
- Pharmacovigilance
Background:
- Tenofovir (TDF) is a key antiretroviral medication.
- Renal function deterioration is a known adverse effect of TDF.
- Local data on TDF-associated nephrotoxicity incidence and risk factors were previously limited.
Purpose of the Study:
- To determine the incidence of nephrotoxicity in HIV-infected patients on TDF-based regimens.
- To identify risk factors associated with TDF-induced renal function decline.
Main Methods:
- Retrospective cohort study of 440 HIV-infected adults.
- Data collected from electronic medical and pharmacy records.
- Analysis of estimated glomerular filtration rate (eGFR) decline and associated risk factors.
Main Results:
- An estimated incidence of TDF-related renal dysfunction was 12 per 100 person-years.
- A decline in eGFR of 25% or more was observed in 15.2% of patients.
- Baseline moderate/severe renal impairment, age >50, and CD4 count <50 were significant risk factors for renal decline.
Conclusions:
- The incidence of TDF-related renal dysfunction is significant.
- Preexisting renal impairment, advanced age, and low CD4 counts are key predictors.
- Increased awareness of TDF nephrotoxicity is crucial, especially with its escalating use in Malaysia.
