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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Clinical and experimental research in antituberculosis drug-induced hepatotoxicity: a review

Udhaya Lavinya Baskaran1, Evan Prince Sabina1

  • 1School of Biosciences and Technology, VIT University, Vellore-632014, Tamilnadu, India.

Journal of Integrative Medicine
|January 16, 2017
PubMed

Insights

Antituberculosis drug-induced liver injury (ATD-HILI) is a common adverse effect. This review explores ATD-HILI mechanisms and alternative therapies, as drug withdrawal is the only current option.

Area of Science:

  • Pharmacology
  • Hepatology
  • Infectious Diseases

Background:

  • Drug-induced liver injury (DILI) is a significant concern in tuberculosis treatment.
  • Antituberculosis drugs (ATDs) are frequently associated with hepatotoxicity.
  • Current management often necessitates ATD withdrawal, limiting treatment efficacy.

Purpose of the Study:

  • To review the mechanisms underlying ATD-induced hepatotoxicity.
  • To explore potential alternative therapies for managing ATD-HILI.
  • To provide a comprehensive overview for clinicians and researchers.

Main Methods:

  • Literature review of studies on ATD-HILI.
  • Analysis of research on natural and synthetic compounds for mitigating liver injury.
  • Synthesis of information on underlying mechanisms and alternative treatment strategies.

Main Results:

  • ATD-HILI is a complex condition with various contributing factors.
  • Several natural and synthetic compounds show promise in preclinical studies.
  • Limited clinical options exist beyond drug cessation.

Conclusions:

  • Understanding ATD-HILI mechanisms is crucial for developing targeted therapies.
  • Alternative therapeutic strategies are needed to prevent treatment interruption.
  • Further research into novel agents is warranted to improve patient outcomes.

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