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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Dengue infection in pregnancy and its impact on the placenta
Christiane Fernandes Ribeiro1, Vânia Glória Silami Lopes2, Patrícia Brasil3
1Departamento Materno-infantil, Universidade Federal Fluminense, 303, Marquês do Paraná Street, 3° floor, Centro, Niterói, Rio de Janeiro 24033-900, Brazil.
Abstract:
A histopathological and immunohistochemical study was conducted in placental tissues and retained products of conception from 24 patients with confirmed dengue infection during pregnancy. The immunohistochemical assay was positive for dengue virus in 19 placental and three ovular remnants analyzed. The light microscopic findings were signs of hypoxia, choriodeciduitis, deciduitis and intervillositis and the viral antigens were found in cytoplasmic of the trophoblast, villous stroma and decidua. Our results suggest that immunohistochemistry could be used as a laboratory confirmation method for dengue in pregnant women, especially in endemic areas when embedded material is the only material available.
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