Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:03

Long-term Depression

3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.5K
Long-term Depression01:05

Long-term Depression

33.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fructose Intake Is Associated with Brain Metabolic Reprogramming and Exacerbation of Alzheimer-like Alterations in APP/PS1 Mice.

International journal of molecular sciences·2026
Same author

Efficacy of Long-Acting Injectable Cabotegravir and Rilpivirine Compared With Daily Oral Antiretroviral Therapy in Patients With HIV: A Systematic Review.

Cureus·2026
Same author

Activated astrocytes increase dehydroascorbic acid uptake, changing intracellular metabolism and vitamin C recycling and emulating neuropathological conditions.

Redox biology·2026
Same author

Intermittent Fasting: A Metabolically Focused Therapeutic Strategy for Obesity.

Nutrients·2026
Same author

Metabolic Reprogramming by Andrographolide: Enhanced Pentose Phosphate Pathway and Antioxidant Capacity in Cortical Astrocytes.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Adipokines at the Metabolic-Brain Interface: Therapeutic Modulation by Antidiabetic Agents and Natural Compounds in Alzheimer's Disease.

Pharmaceuticals (Basel, Switzerland)·2025

Related Experiment Video

Updated: Mar 8, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K

Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing

Paulina Salazar1, Pedro Cisternas2, Juan Francisco Codocedo1

  • 1Centro de Envejecimiento y Regeneración (CARE UC), Departamento de Biología Celular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|January 16, 2017
PubMed
Summary

Early-life hypothyroidism in rats impairs learning and memory by affecting hippocampal plasticity and function. This study highlights the critical role of thyroid hormones in early brain development and cognitive performance.

Keywords:
Cognitive performanceGlucose metabolismHippocampusHypothyroidism

More Related Videos

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

19.9K
Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
09:51

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

12.2K

Related Experiment Videos

Last Updated: Mar 8, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
07:13

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

19.9K
Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
09:51

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

12.2K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Developmental Biology

Background:

  • Thyroid hormones are crucial for brain development and function.
  • Hypothyroidism, particularly in early life, can have lasting impacts on cognitive abilities.
  • The specific effects of early-onset hypothyroidism on hippocampal function remain incompletely understood.

Purpose of the Study:

  • To investigate the impact of early postnatal hypothyroidism on cognitive functions, focusing on the hippocampus.
  • To assess learning and memory deficits in a rat model of early-onset hypothyroidism.
  • To explore the underlying mechanisms, including hippocampal plasticity, glucose metabolism, and oxidative stress.

Main Methods:

  • Hypothyroidism was induced in young rats using 6-propyl-2-thiouracil (PTU) from postnatal day 21 for 4 weeks.
  • Cognitive performance was evaluated using the Morris Water Maze test.
  • Hippocampal plasticity (LTP/LTD), glucose utilization, oxidative stress markers, and MAP2 expression were assessed.

Main Results:

  • PTU-induced hypothyroidism significantly impaired learning and memory in rats.
  • Cognitive deficits correlated with reduced hippocampal plasticity (LTP/LTD).
  • Hypothyroidism led to decreased hippocampal glucose utilization, increased oxidative stress, and reduced MAP2 levels.

Conclusions:

  • Early-onset hypothyroidism in rats causes significant cognitive impairment.
  • These impairments are associated with altered hippocampal plasticity, reduced glucose metabolism, and increased oxidative stress.
  • The findings underscore the critical role of thyroid hormones in early brain development and hippocampal function.