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MicroRNAs in pituitary tumors

Anne Wierinckx1, Magali Roche2, Catherine Legras-Lachuer3

  • 1Université Lyon 1, Université de Lyon, Lyon, France; Institut Universitaire de Technologie Lyon1, Université de Lyon, F-69622 Villeurbanne Cedex, France; INSERM U1052, Cancer Research Center of Lyon, F-69373 Lyon Cedex 08, France; CNRS UMR 5286, Cancer Research Center of Lyon, F-69373 Lyon Cedex 08, France; ProfileXpert, SFR-Est, CNRS UMR-S3453, INSERM US7, F-69373 Lyon Cedex 08, France.

Molecular and Cellular Endocrinology
|January 17, 2017
PubMed

Insights

MicroRNAs play a crucial role in pituitary hormone synthesis and pituitary tumors. This review details microRNA involvement in tumor development, progression, and potential therapeutic strategies.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • Their presence in the pituitary gland is established, but research often focuses on pituitary tumors.
  • Understanding miRNA roles in normal pituitary function and tumorigenesis is crucial.

Purpose of the Study:

  • To review the involvement of miRNAs in pituitary hormone synthesis.
  • To provide an inventory of miRNA suppressors and inducers in pituitary tumors.
  • To summarize the functional roles and regulatory mechanisms of miRNAs in pituitary tumorigenesis.

Main Methods:

  • Literature review of scientific publications on miRNAs and pituitary tumors.
  • Analysis of miRNA involvement in hormone synthesis.
  • Compilation of data on miRNA regulators and modulators in pituitary tumors.

Main Results:

  • miRNAs are implicated in both normal pituitary hormone synthesis and the development of pituitary tumors.
  • A comprehensive list of miRNA suppressors and inducers of pituitary tumors is presented.
  • Key mechanisms regulating miRNAs, including transcription factors and epigenetic modifications, are discussed.

Conclusions:

  • miRNAs are critical regulators in pituitary tumorigenesis, progression, and aggressiveness.
  • Mechanisms of miRNA regulation and modulation offer potential therapeutic targets.
  • Investigating miRNA expression in body fluids may provide valuable diagnostic or prognostic information.
Keywords:
Pituitary tumorsmicroRNAs

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