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Robust causal inference using directed acyclic graphs: the R package 'dagitty'.

Johannes Textor1, Benito van der Zander2, Mark S Gilthorpe3,4

  • 1Department of Tumour Immunology, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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Summary
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The R package "dagitty" brings the DAGitty web application's causal inference capabilities to R, enabling robust epidemiological analysis. It helps detect causal misspecifications and ensures valid inferences across different directed acyclic graphs (DAGs).

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Area of Science:

  • Epidemiology
  • Biostatistics
  • Causal Inference

Background:

  • Directed acyclic graphs (DAGs) are crucial for causal inference in epidemiology.
  • They are used to identify covariate adjustment sets for minimizing confounding bias.
  • The DAGitty web application is a popular tool for drawing and analyzing DAGs.

Purpose of the Study:

  • Introduce the R package 'dagitty' for accessing DAGitty's capabilities within R.
  • Provide new functions for evaluating DAG consistency, enumerating statistically equivalent DAGs, and identifying robust adjustment sets.
  • Enhance causal inference by enabling detection of misspecifications and ensuring valid inferences.

Main Methods:

  • Leveraging the R statistical computing platform.
  • Implementing functions for DAG consistency evaluation against datasets.
  • Developing algorithms for enumerating statistically equivalent DAGs.
  • Identifying exposure-outcome adjustment sets valid across equivalent DAGs.

Main Results:

  • The R package 'dagitty' offers comprehensive DAG analysis within R.
  • Users can evaluate DAG-dataset consistency and identify equivalent DAGs.
  • Robust adjustment sets can be identified, ensuring valid causal inferences.

Conclusions:

  • The 'dagitty' R package empowers epidemiologists with advanced causal inference tools.
  • It facilitates the detection of causal misspecifications in DAGs.
  • This leads to more robust and reliable epidemiological findings.