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Updated: Mar 8, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

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Novel Uses for Lipid-Lowering Agents

Megan Brafford May1, Ashley Glode1

  • 1Baptist Health Lexington, Lexington, Kentucky; University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Journal of the Advanced Practitioner in Oncology
|January 17, 2017
PubMed

Insights

Statins, used to lower cholesterol, may help prevent and treat cancer by inhibiting tumor growth and promoting cancer cell death. Further research is exploring their role in oncology.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Statins reduce mevalonate pathway products.
  • The mevalonate pathway is implicated in cancer development.

Approach:

  • Review of existing literature on statin's role in cancer.
  • Examination of statins' pleiotropic effects relevant to cancer.

Key Points:

  • Statins inhibit cell proliferation, enhance apoptosis, and modulate angiogenesis.
  • Experimental studies show statins can inhibit tumor growth and metastasis.
  • Statins' mechanisms suggest potential in cancer prevention and treatment.

Conclusions:

  • Growing evidence supports investigating statins for cancer prevention and therapy.
  • This review synthesizes literature on statins' anti-cancer applications.

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