Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor
Thomas Hanauer1, Richard J Hopkinson2, Kamal Patel3
1Institute of Organic Chemistry, Technische Universität Bergakademie Freiberg, Leipziger Strasse 29, Freiberg, Sachsen, Germany. tgruber@lincoln.ac.uk.
Abstract:
Chemical tools that recognise post-translational modifications have promising applications in biochemistry and in therapy. We report a simple carboxycalixarene that selectively binds molecules containing di/trimethylammonium moieties in isolation, in cell lysates and when incorporated in histone peptides. Our findings reveal the potential of using carboxycalixarene-based receptors to study epigenetic regulation.
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