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Related Experiment Video

Updated: Mar 8, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Psoriasiform dermatitides: A brief review.

Mark R Wick1

  • 1Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Room 3020, University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, United States.

Seminars in Diagnostic Pathology
|January 18, 2017
PubMed
Summary

Psoriasis vulgaris (PV) can look like other skin conditions due to varied histology. This review helps differentiate PV from similar disorders, aiding accurate diagnosis.

Keywords:
Chronic spongiotic dermatitisLichen simplex chronicusPityriasis rubra pilarisPrurigo nodularisPsoriasiform dermatitisPsoriasis vulgarisReiter syndromeSyphilis

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Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Psoriasis vulgaris (PV) presents diverse histologic features, influenced by treatment status.
  • This variability can lead to diagnostic confusion with other skin disorders characterized by acanthosis.

Purpose of the Study:

  • To review the clinicopathologic features of psoriasis vulgaris.
  • To distinguish PV from its differential diagnoses that mimic its appearance.

Main Methods:

  • Literature review of clinicopathologic studies on psoriasis vulgaris and related conditions.
  • Comparative analysis of histologic findings.

Main Results:

  • Psoriasis vulgaris exhibits a range of histological patterns.
  • Several dermatoses, including chronic spongiotic dermatitides, lichen simplex chronicus, prurigo nodularis, pityriasis rubra pilaris, psoriasiform secondary syphilis, and Reiter syndrome, can mimic PV.

Conclusions:

  • Accurate diagnosis of psoriasis vulgaris requires careful clinicopathologic correlation.
  • Awareness of mimickers is crucial for effective management of psoriasiform conditions.