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Stage IV advanced diffuse large B-cell lymphoma in human immunodeficiency virus infection with achieving cure by

Do Hyoung Lim1, Ji-Young Rhee2, Keon Woo Park1

  • 11 Division of Hematology-Oncology, Department of Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Republic of Korea.

International Journal of STD & AIDS
|January 18, 2017
PubMed

After the introduction of highly active antiretroviral therapy (HAART), there has been a decrease in the incidence of lymphoma among the HIV-infected population and also significantly improved survival rates. We describe a remarkable case of an HIV-infected patient with advanced stage IV diffuse large B-cell lymphoma (DLBCL), completely regressed with the use of HAART alone. He remained disease-free for 6 years and he achieved cure without chemotherapy. Although several cases of low-grade lymphoma with complete regression were reported, we could not find any case of stage IV high-grade malignant lymphoma with HAART alone in complete remission for over 5 years from our review of the literature. This unique case shows the importance of HAART in improving survival and achieving cure in HIV-high-grade malignant lymphoma.

Keywords:
Diffuse large B-cell lymphomaHIV infectionantiretroviral therapyspontaneous regression

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