Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liver Tumor Induction.

Stan D Vesselinovitch1

  • 1Departments of Radiology and Pathology, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637.

Toxicologic Pathology
|January 18, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Comparison of Standard Clinical Pathology Parameter Values in Fasted and Fed Rats and Non-human Primates.

Toxicologic pathology·2026
Same journal

Time-Dependent Autolysis in Ex Vivo-Maintained Rat Tissue in Saline: A Descriptive Study and Practical Guidance for Histopathologic Assessment.

Toxicologic pathology·2026
Same journal

New Approach Methodologies (NAMs) for Carcinogenicity Evaluation.

Toxicologic pathology·2026
Same journal

2025 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: Pathology Working Groups (PWGs) in Toxicologic Pathology.

Toxicologic pathology·2026
Same journal

Toxicologic Pathology Forum*: Opportunities and Challenges in the Use of Artificial Intelligence in Nonclinical Toxicologic Histopathology Evaluations.

Toxicologic pathology·2026
Same journal

New Modalities and Carcinogenicity Assessment.

Toxicologic pathology·2026

Accurate classification of rodent liver lesions is crucial for carcinogenicity assessment. Differentiating between benign hyperplasia and malignant tumors requires careful evaluation of morphology and biological behavior for reliable risk assessment.

Area of Science:

  • Toxicology
  • Hepatocarcinogenesis Research
  • Rodent Bioassays

Background:

  • Nodular liver lesions in rodents present diagnostic and interpretational challenges.
  • Distinguishing benign from malignant liver tumors is essential for accurate classification.
  • Spontaneous liver tumors in some mouse strains complicate interpretation of experimental findings.

Purpose of the Study:

  • To address diagnostic and interpretational questions regarding rodent liver lesions.
  • To clarify the distinction between neoplastic nodules and hyperplastic nodules.
  • To investigate mechanisms of tumor promotion versus initiation in hepatocarcinogenesis.

Main Methods:

  • Correlation of lesion morphology with biological behavior for tumor classification.

Related Experiment Videos

  • Inclusion of "stop"-type treatment in chronic carcinogenicity bioassays.
  • Evaluation of histochemically altered foci as indicators of potential hepatocarcinogenicity.

    • Main Results:

    • The term "neoplastic nodule" for rat liver lesions is often misleading; many regress or remodel.
    • Histochemically altered foci indicate potential hepatocarcinogenicity but are not bona fide cancer.
    • Factors like hormonal environment, caloric intake, and age influence liver tumor development.

    Conclusions:

    • Careful differentiation between hyperplasia, benign neoplasia, and malignant tumors is vital.
    • Rodent bioassay interpretation requires consideration of spontaneous tumor incidence and influencing factors.
    • Relevance of rodent carcinogenicity data to humans necessitates evaluating pharmacokinetics and extrahepatic neoplasia.