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Four-Step Total Synthesis of Selaginpulvilin D
Madison J Sowden1, Michael S Sherburn1
1Research School of Chemistry, Australian National University , Canberra, ACT 2601, Australia.
Organic Letters
|January 18, 2017
Abstract:
An extremely concise total synthesis of a potent phosphodiesterase-4 inhibitory natural product, selaginpulvilin D, is reported. The synthesis features a one-pot, 3-fold electrophilic aromatic substitution sequence to assemble a 9,9-diarylfluorene core. The approach allows access to useful quantities of a selaginpulvilin natural product for the first time.
