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Postproduction Processing of Electrospun Fibres for Tissue Engineering
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Competent processing techniques for scaffolds in tissue engineering.

Ranjna C Dutta1, Madhuri Dey2, Aroop K Dutta3

  • 1ExCel Matrix Biological Devices (P) Ltd, Hyderabad, India; Laboratory for Biomaterilas, Materials Research Centre, Indian Institute of Science, Bangalore, India.

Biotechnology Advances
|January 18, 2017
PubMed
Summary
This summary is machine-generated.

Developing advanced biomaterial scaffolds is crucial for tissue engineering (TE). This review explores material requirements and fabrication techniques for creating functional, cell-interactive 3D scaffolds that mimic the extracellular matrix (ECM).

Keywords:
Extracellular matrix (ECM)Fabrication techniquesRegenerative medicineScaffoldsTissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Functional tissue engineering requires integrated development of extracellular matrix (ECM) mimicking scaffolds and tissue-specific cells.
  • Cell-interactive 3D scaffolds with optimal porosity and mechanical strength are central to tissue engineering (TE).

Purpose of the Study:

  • To review material requirements for tissue engineering from various perspectives.
  • To discuss the advantages and disadvantages of advanced fabrication techniques for large-scale manufacturing of tissue-specific ECM mimics.

Main Methods:

  • Analysis of material requirements for diverse tissue engineering applications.
  • Discussion of advanced fabrication techniques, including those allowing material blends and combinatorial processing.

Main Results:

  • New techniques offer flexibility in using material blends for enhanced mechanical strength and biocompatibility.
  • Combinatorial approaches integrating multiple materials and processing techniques are advantageous.

Conclusions:

  • Advanced fabrication techniques are essential for creating sophisticated, tissue-specific ECM mimics.
  • Material selection and processing strategies significantly impact the success of ex vivo tissue engineering.